Pathophysiology Of Type 2 Diabetes Mellitus Pdf

In an individual who has type 2 diabetes mellitus t2dm a dysfunction exists with cells that are normally sensitive to insulin.

Pathophysiology of type 2 diabetes mellitus pdf. Leibel naomi berrie diabetes center 25 february 2008 body mass index chart 25 29 9 overweight. It has previously been referred to as non insulin dependent diabetes mellitus. Type 2 diabetes mellitus is a heterogeneous syndrome characterized by abnormalities in carbohydrate and fat metabolism. Development of type 2 diabetes genetic factors the insulin secretory capacity of japanese is one half that of western people decreased insulin secretion interaction more than 30 fold increase in 50 years 8 9 million patients 13 2 million pre diabetics fig.

The causes of type 2 diabetes are multi factorial and include both genetic and environmental elements that affect beta cell function and tissue muscle liver adipose tissue pancreas insulin sensitivity. The condition is usually diagnosed in people aged over. Type 2 diabetes mellitus dm2 is a comp lex metabolic and endocrine disorder resulting from the inter action betw een geneti c and en vironmental fact ors whi ch. Type 1 and type 2 diabetes results when beta cells in the pancreas fail to produce enough insulin the hormone that regulates blood sugar.

However since many patients with type 2 diabetes require insulin this terminology causes confusion and should no longer be used. One approach to treating diabetes is to stimulate. Diagnosis of conditions resembling type 2 diabetes chapters 13 3 4 and 13 3 5 and the pathophysiology of hypertension macro and microvascular disease chapters 13 5 13 6 1 and 13 6 4 and the role of genetic factors in the aetiology of type 2 diabetes chapter 13 3 1 are described in detail elsewhere. Diabetes mellitus pathophysiology pathogenesis etiology.

Type 2 is the most common form of diabetes accounting for 85 90 of all cases. Shows progression overtime in type 2 diabetes although aging obesity insufficient energy consumption alcohol drinking smoking etc are independent risk factors of pathogenesis of type 2 diabetes mellitus.